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Literature summary extracted from

  • Hong, X.; Lei, L.; Kuenert, B.; Naredla, R.; Applequist, S.E.; Grandien, A.; Glas, R.
    Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors (2007), Cancer Res., 67, 7165-7174.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.14.10 medicine TPPIIcan be targeted for inhibition of tumor therapy resistance Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.4 Ala-Ala-Phe-chloromethylketone
-
 Homo sapiens
3.4.11.4 Ala-Ala-Phe-chloromethylketone
-
 Mus musculus
3.4.11.4 butabindide
-
 Homo sapiens
3.4.11.4 butabindide
-
 Mus musculus
3.4.11.4 Z-Gly-Leu-Ala-OH
-
 Homo sapiens
3.4.11.4 Z-Gly-Leu-Ala-OH
-
 Mus musculus
3.4.14.10 Z-Gly-Leu-Ala-OH
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.4 cytosol
-
 Mus musculus 5829
-
3.4.11.4 cytosol
-
 Homo sapiens 5829
-
3.4.11.4 nucleus subsequent relocalization into the nucleus following gamma-irradiation Mus musculus 5634
-
3.4.14.10 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.4 Homo sapiens
-
-
-
3.4.11.4 Mus musculus
-
-
-
3.4.14.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.4 EL-4 cell
-
 Mus musculus
-
3.4.11.4 HeLa cell
-
 Homo sapiens
-
3.4.11.4 lymphoma cell
-
 Mus musculus
-
3.4.11.4 lymphoma cell
-
 Homo sapiens
-
3.4.14.10 lymphoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.4 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Mus musculus ?
-
 ?
3.4.11.4 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.10 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.4 TPPII
-
 Mus musculus
3.4.11.4 TPPII
-
 Homo sapiens
3.4.11.4 tripeptidyl-peptidase II
-
 Mus musculus
3.4.11.4 tripeptidyl-peptidase II
-
 Homo sapiens
3.4.14.10 TPPII
-
 Homo sapiens
3.4.14.10 tripeptidyl peptidase II
-
 Homo sapiens